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Taldenaplex 20

Taldenaplex 20 (Tadalafil) is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis. In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003 as the third impotence pill after sildenafil (Viagra) and vardenafil (Levitra). Due to its 36-hour effect it is also known as the weekend pill. It should be noted that the drug has not been formally studied in regard to multiple sexual attempts during a 36 hour period. Tadalafil is also currently undergoing Phase III clinical trials for the treatment of pulmonary hypertension. MECHANISM OF ACTION Taldenaplex 20 (Tadalafil) works by inhibiting PDE5, an enzyme found primarily in the arterial wall smooth muscle tissue of the penis and the lungs. A 20 mg dose of tadalafil is comparable to a 100 mg dose of sildenafil (Viagra). By inhibiting PDE5, tadalafil relaxes blood vessels in the penis, thereby increasing blood flow and aiding in erection. Part of the physiological process of erection involves the parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) in the corpus cavernosum, resulting in increased inflow of blood and an erection. Taldenaplex 20 (Tadalafil) is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of tadalafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, tadalafil should not cause an erection. Other drugs that operate by the same mechanism include sildenafil (Viagra) and vardenafil (Levitra). Taldenaplex 20 (Tadalafil) is currently undergoing clinical trials for the treatment of pulmonary hypertension. The clinical trials are based on tadalafil's inhibitiong of PDE5. It is hoped that by inhibiting this enzyme, tadalafil will prove effective in opening up blood vessels in the lungs, lowering pulmonary arterial resistance and pressure, and thus reducing the workload of the right ventricle of the heart. SIDE EFFECTS The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and the symptom usually disappears after 48 hours. In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, including diabetics. An investigation is currently ongoing.

Taldenaplex 10

Taldenaplex 10 (Tadalafil) is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis. In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003 as the third impotence pill after sildenafil (Viagra) and vardenafil (Levitra). Due to its 36-hour effect it is also known as the weekend pill. It should be noted that the drug has not been formally studied in regard to multiple sexual attempts during a 36 hour period. Tadalafil is also currently undergoing Phase III clinical trials for the treatment of pulmonary hypertension. MECHANISM OF ACTION Taldenaplex 10 (Tadalafil) works by inhibiting PDE5, an enzyme found primarily in the arterial wall smooth muscle tissue of the penis and the lungs. A 10 mg dose of tadalafil is comparable to a 100 mg dose of sildenafil (Viagra). By inhibiting PDE5, tadalafil relaxes blood vessels in the penis, thereby increasing blood flow and aiding in erection. Part of the physiological process of erection involves the parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) in the corpus cavernosum, resulting in increased inflow of blood and an erection. Taldenaplex 10 (Tadalafil) is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of tadalafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, tadalafil should not cause an erection. Other drugs that operate by the same mechanism include sildenafil (Viagra) and vardenafil (Levitra). Taldenaplex 10 (Tadalafil) is currently undergoing clinical trials for the treatment of pulmonary hypertension. The clinical trials are based on tadalafil's inhibitiong of PDE5. It is hoped that by inhibiting this enzyme, tadalafil will prove effective in opening up blood vessels in the lungs, lowering pulmonary arterial resistance and pressure, and thus reducing the workload of the right ventricle of the heart. SIDE EFFECTS The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and the symptom usually disappears after 48 hours. In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, including diabetics. An investigation is currently ongoing.

Stanoplex 50

Average Dose: 50-100 mg/day(M) Women 25-50 mg/week(F)
Half Life: 48 - 72 hours
Water Retention: Rare
Aromatization: No
DHT Conversion: None

Stanoplex is a popular brand name for the anabolic steroid stanozolol. This compound is a derivative of dihydrotestosterone, although its activity is much milder than this androgen in nature. It is technically classified as an anabolic steroid, shown to exhibit a slightly greater tendency for muscle growth than androgenic activity in early studies. While dihydrotestosterone really only provides androgenic side effects when administered, stanozolol instead provides quality muscle growth. Admittedly the anabolic properties of this substance are still mild in comparison to many stronger compounds, but it is still a reliable builder. Its efficacy as an anabolic could even be comparable to Dianabol, however Stanabol® does not carry with it the same tendency for water retention. Stanozolol also contains the same c17 methylation we see with Dianabol, an alteration used so that oral administration is possible. To spite this design however, there are many injectable versions of this steroid produced. Structurally stanozolol is not capable of converting into estrogen. Likewise an antiestrogen is not necessary when using this steroid, gynecomastia not being a concern even among sensitive individuals. Since estrogen is also the culprit with water retention, instead of bulk Stanabol® produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are a major concern. It is also very popular among athletes in combination strength/speed sports such as Track and Field. In such disciplines one usually does not want to carry around excess water weight, and may therefore find the raw muscle-growth brought about by Stanabol® quite favorable over the lower quality mass gains of more estrogenic agents. For men the usual dosage of Stanabol® is 15-30mg per day. It is often combined with other steroids depending on the desired result. For bulking purposes, a stronger androgen like testosterone, Dianabol or Androlic 50® is usually added. Here Stanabol® will balance out the cycle a bit, giving us good anabolic effect with lower overall estrogenic activity than if taking such steroids alone. The result should be a considerable gain in new muscle mass, with a more comfortable level of water and fat retention. For contest and dieting phases we could alternately combine Stanabol® with a non-aromatizing androgen such as Parabolan® Tablets or Restandol®(Andriol). Such combinations should help bring about the strongly defined, hard look of muscularity so sought after among bodybuilders. Older, more sensitive individuals can otherwise addition compounds like Primobolan® or Deca-Durabolin® when wishing to stack this steroid. Here we should see good results and fewer side effects than is to be expected with standard androgen therapies. Women will take somewhere in the range of 5-l0mg per day. Although this compound is only moderately androgenic, the risk of virilization symptoms should remain a concern. With the structural (c17-AA) alteration, the tablets will also place a higher level of stress on the liver than the injectable (which avoids the "first pass"). During longer or higher dosed cycles, liver values should therefore be watched closely through regular blood work. Although less common, the possibility of liver damage cannot be excluded with the injectable however. While it does not enter the body through the liver, it is still broken down by it, providing a lower (but more continuous) level of stress. Such stress would of course be amplified when adding other c17-AA oral compounds to a cycle of stanozolol. When using such combinations, cautious users would make every effort to limit the length of the cycle (preferably 6 to 8 weeks). It is also of note that both versions of stanozolol have been linked to strong adverse changes in HDULDL cholesterol levels. This side effect is common with anabolic steroid therapy, and obviously can become a health concern as the dose/duration of intake increase above normal. The oral version should have a greater impact on cholesterol values than the injectable due to the method of administration, and may therefore be the worse choice of the two for those concerned and this side effect. As discussed in the opening section of this book, the oral use of stanozolol can also have a profound impact on levels of SHBG (sex hormone-binding globulin). This admittedly is characteristic of all anabolic/androgenic steroids, however its potency and form of administration make stanozolol particularly noteworthy in this regard. Since plasma binding proteins such as SHBG act to temporarily constrain steroid hormones from exerting activity, this effect would provide a greater percentage of free (unbound) steroid hormone in the body. This may amount to an effective mechanism in which stanozolol could increase the potency of a concurrently used steroid. To further this purpose we could also addition Proviron® (1 methyl-dihydrotestosterone), which has an extremely high affinity for SHBG. This affinity may cause Proviron® to displace other weaker substrates for SHBG (such as testosterone), another mechanism in which the free hormone level may be increased. Adding Stanabol® and Proviron® to your next testosterone cycle may therefore prove very useful, markedly enhancing the free state of this potent muscle building androgen.

Methanoplex 50

Average Dose: Men 15-50 mg/day(M) Women 5-10 mg/day(F)
Half Life: 6-8 hours
Water Retention: Yes
Aromatization: Yes
DHT Conversion: No

Methanoplex is an orally applicable steroid with a great effect on protein metabolism. Methandienone iis a derivative of testosterone and has a very strong anabolic and androgenic properties. It has a great effect on protein metabolism and promotes protein synthesis. This effect manifests itself in by creating a positive nitrogen balance, supporting the builidup of protein and, thus, skeletal muscle mass. Methandienone also induces an improved sense of well-being.

Methandienone is a derivative of testosterone, exhibiting strong anabolic and moderate androgenic properties. This compound was first made available in 1960, and it quickly became the most favored and widely used anabolic steroid in all forms of athletics. This is likely due to the fact that it is both easy to use and extremely effective. In the U.S. Dianabol production had meteoric history, exploding for quite some time, then quickly dropping out of sight. Many were nervous in the late 80\\\'s when the last of the U.S. generics were removed from pharmacy shelves, the medical community finding no legitimate use for the drug anymore. But the fact that Dianabol has been off the U.S. market for over 10 years now has not cut its popularity. It remains the most commonly used black market oral steroid in the U.S. As long as there are countries manufacturing this steroid, it will probably remain so.

Similar to testosterone and Anadrol 50, Methandienone (other known as Dianabol) is a potent steroid, but also one which brings about noticeable side effects. For starters methandienone is quite estrogenic. Gynecomastia is often a concern during treatment, and may present itself quite early into a cycle (particularly when higher doses are used). At the same time water retention can become a pronounced problem, causing a notable loss of muscle definition as both subcutaneous water and fat build. Sensitive individuals may therefore want to keep the estrogen under control with the addition of an anti-estrogen such as Nolvadex and/or Proviron. The stronger drugs Arimidex, Femara, or Aromasin (antiaromatase) would be a better choice if available.

In addition, androgenic side effects are common with this substance, and may include bouts of oily skin, acne and body/facial hair growth. Aggression may also be increased with a potent steroid such as this, so it would be wise not to let your disposition change for the worse during a cycle. With Dianabol there is also the possibility of aggravating a male pattern baldness condition. Sensitive individuals may therefore wish to avoid this drug and opt for a milder anabolic such as Deca-Durabolin. While Dianabol does convert to a more potent steroid via interaction with the 5-alpha reductase anzyme (the same enzyme responsible for converting testosterone to dihydrotestosterone), it has extremely little affinity to do so in the human body\\\'s. The androgenic metabolite 5alpha dihydromethandrostenolone is therefore produced only in trace amounts at best. Therefore the use of Proscar/Propecia would serve no real purpose.

Being moderately androgenic, Methandienone is really only a popular steroid with men. When used by women, strong virilization symptoms are of course a possible result. Some do however experiment with it, and find low doses (5mg) of this steroid extremely powerful for new muscle growth. Whenever taken, Methandienone (dianabol) will produce exceptional mass and strength gains. It\\\'s effectiveness is often compared to other strong steroids like testosterone and Anadrol 50, and it is likewise a popular choice for bulking purposes. A daily dosage of 20-40mg is enough to give almost anybody dramatic results. Some do venture much higher in dosage, but this practice usually leads to a more profound incidence of side effects. It additionally combines well with a number of other steroids. It is noted to mix particularly well with the mild anabolic Deca-Durabolin. Together one can expect an exceptional muscle and strength gains, with side effects not much worse than one would expect from Dianabol alone. For all out mass, a long acting testosterone ester like enanthate can be used. With the similarly high estrogenic/androgenic properties of this androgen, side effects may be extreme with such a combination however. Gains would be great as well, which usually makes such an endeavor worthwhile to the user. As discussed earlier, ancillary drugs can be added to reduce the side effects associated with this kind of cycle.

In order to withstand oral administration, this compound is c17 alpha alkylated. We know that this alteration protects the drug from being deactivation by the liver (allowing nearly all of the drug entry into the bloodstream), however it can also be toxic to this organ. Prolonged exposure to c17 alpha alkylated substances can result in actual damage, possibly even the development of certain kinds of cancer. To be safe one might want to visit the doctor a couple of times during each cycle to keep an eye on their liver enzyme values. Cycles should also be kept short, usually less than 8 weeks long to avoid doing any noticeable damage. Jaundice (bile duct obstruction) is usually the first visible sign of liver trouble, and should be looked out for. This condition produces an unusual yellowing of the skin, as the body has trouble processing bilirubin. In addition to the skin, the whites of the eyes may also yellow, a clear indicator of trouble. Should this occur the drug should be discontinued immediately and a doctor visited. This is usually a point where further, permanent damage can be avoided.

It is also interesting to note that methandienone is structurally identical to boldenone (EQ), except that it contains the added c17 alpha alkyl group discussed above. This fact makes clear the impact of altering a steroid in such a way, as these two compounds appear to act very differently in the body. The main dissimilarity seems to lie in the tendency for estrogenic side effects, which seems to be much more pronounced with Dianabol. Equipoise is known to be quite mild in this way, and users therefore commonly take this drug without any need of an anti-estrogen. Dianabol is much more estrogenic not because it is more easily aromatized, as in fact the 17 alpha methyl group and c1-2 double bond both slow the process of aromatization. The problem is that methanmdienone converts to l7alpha methylestradiol, a more biologically active form of estrogen than regular estradiol. But Dianabol also appears to be much more potent in terms of muscle mass compared to boldenone, supporting the notion that estrogen does play an important role in anabolism. In fact boldenone and methandienone differ so much in their potencies as anabolics that the two are rarely though of as related. As a result, the use of Dianabol is typically restricted to bulking phases of training while Equipoise is considered an excellent cutting or lean-mass building steroid.

The half-life of Dianabol is only about 3 to 4 hours, a relatively short time. This means that a single daily dosage schedule will produce a varying blood level, with ups and downs throughout the day. The user likewise has a choice, to either split up the tablets during the day or to take them all at one time. The usual recommendation has been to divide them and try to regulate the concentration in your blood. This however, will produce a lower peak blood level than if the tablets were taken all at once, so there may be a trade off with this option. The steroid researcher Bill Roberts also points out that a single-episode dosing schedule should have a less dramatic impact on the hypothalamic-pituitary-testicular axis, as there is a sufficient period each day where steroid hormone levels are not extremely exaggerated. I tend to doubt hormonal stability can be maintained during such a cycle however, but do notice that anecdotal evidence often still supports single daily doses to be better for overall results. Perhaps this is the better option. Since we know the blood concentration will peak about 1.5 to 3 hours after administration, we may further wonder the best time to take our tablets. It seems logical that taking the pills earlier in the day, preferably some time before training, would be optimal. This would allow a considerable number of daytime hours for an androgen rich metabolism to heighten the uptake of nutrients, especially the critical hours following training.

Mastaplex 200

Mastaplex is a synthetic derivative of dihydrotestosterone, displaying a potent androgenic effect that is responsible for increases in muscle density and hardness and a moderate anabolic effect that creates a positive nitrogen balance in humans and promotes protein synthesis. Since it is a derivative of dihydrotestosterone, dromastolone does not aromatize in any dosage and thus it cannot be converted into estrogen. Therefore, estrogen-related water retention is eliminated. Mastaplex combines the fast-acting propionate form with the longer acting enanthate form.

Letroplex

Letroplex (Letrozole) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer.

Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Letroplex blocks production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and Letroplex does not reduce production of mineralo- or corticosteroids. In contrast, the antiestrogenic action of tamoxiplex, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production.

Stanaplex 50

Anabolic steroids such as Stanaplex are synthetic derivatives of the male hormone testosterone. Stanozolol has a pronounced anabolic effect with fewer masculinizing side effects than testosterone and some other synthetic anabolic steroids. Anabolic steroids are used in stimulating appetite and increasing weight gain, strength, and vigor. They should be used as a part of an overall program with other supportive and nutritional therapies.

This is a very popular anabolic steroid, which is a derivative of dihydrotestosterone. Winstrol is a relatively low androgenic steroid which will not aromatise. It is moderately toxic to the liver. Very few users report any water retention or any other side effects while using Winstrol. It is a popular drug for cutting in a stack with Primobolan or Parabolan. When stacked with Testosterone it can be very effective for a size and strength gain. Women use the drug quite often, but it can cause virilising effects for some women even at low dosages. Most of the muscle gains made while taking the Winstrol are retained after the drug is discontinued. The injectable veterinarian form is better than the oral. Many feel that the injectable must be administered at least twice a week: some take shots every day for better effects. Dosages range from 3 to 5 cc?s per week for men, 1 to 2 cc's in women. Oral dosage is in the area of 16 to 30 mg per day for men, 4 to 8 mg for women. Winstrol is not too hard to find on the black marked.

Oxyplex

Oxyplex(Oxymetholone) is a synthetic anabolic-androgenic steroid hormone that is structurally related to the male hormone testosterone. Synthetic androgens are used to treat a variety of conditions including hypogonadism and delayed puberty. Androgens are also used to correct hereditary angioneurotic edema, manage carcinoma of the breast, promote a positive nitrogen balance following injury or surgery, and stimulate erythropoiesis.

Considerable amounts of androgens are consumed by athletes in attempts to improve athletic performance. Oxyplex is used to promote weight gain and counteract weakness and emaciation resulting from debilitating diseases, such as advanced HIV infection, and after serious infections, burns, trauma, or surgery. It is marketed as a human prescription drug for the treatment of bone marrow failure anemias and deficient red cell production anemias.

Proscar

By the time men reach about age 50, the prostate may start causing problems. Urinary symptoms begin to trouble many men as they reach middle age. The most common source of symptoms is the prostate gland. More specifically, it is the growth of the prostate gland in some men that can cause urinary tract problems.

PROSCAR is a medication that helps shrink the prostate in many men. This can lead to improvement of symptoms. You may need to take PROSCAR for 6 months or more to see whether it improves your symptoms. PROSCAR has been shown to reduce the risk of a sudden inability to pass urine, referred to as acute urinary retention, and the need for surgerypotential long-term serious consequences of benign prostatic hyperplasia (BPH).

Important Information: PROSCAR is for use by MEN ONLY. Women who are or may potentially be pregnant must NOT use PROSCAR and should not handle crushed or broken tablets of PROSCAR because of the risk of a specific kind of birth defect.

PROSCAR may cause side effects. Side effects due to PROSCAR may include impotence (an inability to have an erection) or less desire for sex. Some men taking PROSCAR may have changes or problems with ejaculation, such as a decrease in the amount of semen released during sex. This decrease in the amount of semen does not appear to interfere with normal sexual function. In some cases these side effects went away while the patient continued to take PROSCAR. In addition, some men may have breast enlargement and/or tenderness. You should promptly report to your doctor any changes in your breasts such as lumps, pain, or nipple discharge.

Primoplex 25

Average Dose: 50-150mg/day(M) 50-75mg/day(F)
Half Life: 4 - 6 hours
Water Retention: No
Aromatization: None
DHT Conversion: no

Indications Primoplex is indicated in the treatment of refractory deficient red cell production anemias. These may include aplastic anemia, myelofibrosis, myelosclerosis, agnogenic myeloid metaplasia, and hypoplastic anemias caused by malignancy or myelotoxic drugs.

Primoplex is indicated in conditions such as chronic infections, extensive surgery, [corticosteroid-induced myopathy, decubitus ulcers, burns] , or severe trauma, which require reversal of catabolic processes or protein sparing effects. These agents are adjuncts to, and not replacements for, conventional treatment of these disorders.

Primoplex (Methenolone Acetate) has been used in certain countries to counteract catabolic states, for example after major trauma.

Lamisil

For those suffering from Foot Fungus infections from the gym, we bring you Lamisil

Lamisil Tablets can help you see clearer, healthier nails again. Lamisil Tablets target the infection in your nail bed. Lamisil Tablets may mean you can start wearing shoes without pain or discomfort.

Just take one tablet every day for 3 months and your nails may look and feel better again (or as directed/recommended by your doctor).

It takes a full 12 weeks of treatment with Lamisil Tablets to treat nail fungus infection in toenails. Treatment for nail fungus infection in fingernails takes only 6 weeks. You may start seeing clearer, healthier nails in just 3 months. Results may vary.

Haloplex

Fluoxymesterone (Haloplex) is an androgenic steroid that is only useful to a small select group of athletes who seeks very specific goals. Athletes tend to use it to increase strength and aggression in the gym or in competitions such as strongman contests, fighting (like boxing) or MMA. The lack of estrogenic activity makes Halotestin perfect for pre-fight usage as weigh-ins would not be effected by water retention. Even in such an events, Fluoxymesterone usage is usually limited to mere few weeks rather then cycled like real steroids for months.

Fluoxymesterone (Haloplex) has poor binding to the AR. Studies have shown the effects to be mostly non-AR mediated. However, it is considered a very toxic oral drug, and a poor choice in most bodybuilding/steroid use applications.

The half life of Fluoxymesterone (Haloplex) is commonly misunderstood. The rumored belief is that 30-90 minutes is the half-life but this rumor is false, the half life of Fluoxymesterone is about 9.5 hours.

Growth Hormone

Average Dose: 2 - 6iu per day
Half Life: varies
Water Retention: Extremely Rare

The use of exogenous sources of Growth Hormone has been popular in the United States for almost 8 years now. Originally, athletes used biologically active forms that were the actual extract of the pituitary glands of cadavers. While production was under way on the synthetic, recombinant DNA versions of this drug, it was discovered that the biologically active form was associated with the formation of a rare brain virus called Creutzveldt Jacob Disease. This was a fatal virus that afflicted a very small number of GH users, none of whom were athletes. In light of this discovery, the FDA removed all of these natural GH versions from the market in the United States. Luckily, the synthetic recombinant versions were approved by the FDA a short time afterwards. These versions were developed after years of experiments with amino acid chains. The first of these versions was patented and produced by Genentech Labs with the brand name Protropin. A short time later, another form of synthetic Growth Hormone gained FDA approval. It was produced by Eli Lilly Labs and brand named Humatrope. This product was allowed to be patented because it was shown to be unique in that it contained a slightly different amino acid chain than the Protropin. The difference was that Humatrope had 191 amino acid chains in sequence and Protropin had 192. For some very complicated reasons, the 191 amino acid configuration has been shown to be more effective. It had been speculated that these synthetic versions of GH would greatly improve the cost effectiveness of using GH, yet that has not been the case.�It has been used extensively by athletes who are attempting to alter their body composition. Growth Hormone itself, is an endogenous hormone produced by the pituitary gland. It exists at especially high levels during the teen years when it promotes growth of almost all tissues. It also contributes to the deposition of protein and promotes the breakdown of fat for use as energy. As the body reaches full maturation, the endogenous levels of GH are substantially diminished. After this, GH is still present in the body but at a substantially lower level where it continues to aid in protein synthesis, RNA and DNA reactions and the conversion of body fat to energy. By introducing an exogenous source of this hormone, athletes are hoping to promote these effects, causing the body to deposit more muscle tissue while atthe same time reducing body fat stores. On paper, GH should work exceptionally well; however, it does not seem to be delivering up to its potential. Most athletes who have experimented with this product end up being disappointed. There is some evidence that exogenous sources of GH are being destroyed by antibodies which appear after the introduction of the synthetic compound. Although the 191 amino acid sequence versions have been shown to produce less of an antibody reaction, they are still not yielding consistent results. I have speculated as to whether the introduction of exogenous GH would yield an appreciable degree of efficacy simply due to the fact that the body does not have sufficient receptor affinity to GH in the post-teen years. A number of athletes claim that GH is not that effective on its own, but in a stack with steroids it can do remarkable things. Perhaps there is some type of actual synergism created by the concomitant use of these two agents. Empirical data suggests that the efficacy of GH is dose related and that the majority of users may not have been taking enough Although Growth Hormone is banned by athletic committees, there is no method for the detection of it which allows drug tested competitors to use this product freely without any ramifications. Adverse reactions to GH use are rare but technically could involveacromegaly (elongation of the feet, forehead and hands). Other possible side effects involve overgrowth of the elbows or jaw, thickening of the skin and a type of diabetes. Effective dosages seem to be in the area of 4 IU/day. Cycle length is usually determined by how long the athlete can afford it. Some take the product for 6 week cycles, others use it year round.

Femara

Active Life: 2-4 days
Drug Class: Aromatase inhibitor (Oral)
Average Dose: 0.5 - 2.5 mg/day
Acne: Yes
Water Retention: No
High Blood Pressure: May reduce bp when using aronatizable steroids
Liver Toxic: Yes, dose dependant
Decrease HPTA function: No

Femara®(generic name is letrozole) is a new drug developed for the treatment of advanced breast cancer in women. Femara is the second in a new class of third-generation selective oral aromatase inhibitors.. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression of such a disease can be halted. This is the basic premise behind Nolvadex, except this drug blocks the action and not production of estrogen. The effects of Femara can be quite dramatic to say the least. A daily dose of one tablet (2.5 mg) can produce estrogen suppression greater than 80 % in treated patients. With the powerful effect this drug has on hormone levels, it is only to be used (clinically) by post-menopausal women whose disease has progressed following treatment with Nolvadex. Side effects like hot flushes and hair thinning can be present, and would no doubt be much more severe in pre-menopausal patients.

For the steroid using male athlete, Femara shows great potential. Up to this point, drugs like Nolvadex and Proviron have been our weapons against excess estrogen. These drugs, especially in combination, do prove quite effective. But Femara appears able to do the job much more efficiently, and with less hassle. Its use is only now catching on, but early reports have been excellent. A single tablet daily, the same dose use clinically, seems to be all one needs for an exceptional effect (some even report excellent results with only 1/4 tablet daily). When used with strong, readily aromatizing androgens such as Dianabol or testosterone, gynecomastia and water retention can be effectively blocked. In combination with Propecia (finasteride), we have a great advance. With the one drug halting estrogen conversion and the other blocking 5-alpha reduction (testosterone, methyltestosterone and Halotestin only), related side effects can be effectively minimized. Here the strong androgen testosterone could theoretically provide incredible muscular growth, while at the same time being as tolerable as nandrolone. Additionally the quality of the muscle should be greater, the athlete appearing harder and much more defined without holding excess water.

There are some concerns with using an aromatase inhibitor such as this during prolonged steroid treatment however. While it will effectively reduce estrogenic side effects, it will also block the beneficial properties of estrogen from becoming apparent (namely its effect on cholesterol values). Studies have clearly shown that when an aromatase inhibitor is used in conjunction with a steroid such as testosterone, suppression of HDL (good) cholesterol becomes much more pronounced. Apparently estrogen plays a role in minimizing the negative impact of steroid use. Since the estrogen receptor antagonist Nolvadex does not display an anti-estrogenic effect on cholesterol values, it is the preferred from of estrogen maintenance for those concerned with cardiovascular health.

Femara has another principle drawback, namely the great price of this drug. Tablets can be quite costly with regular use, but it can ward off the side effects of strong androgens much better than Nolvadex and/or Proviron, making heavy cycles much more comfortable. As the number of countries manufacturing this drug increases, we may be able to look forward to a reduction in price. Privately compounded versions of "liquid Femara have also been formulated "for research purposes" and are currently circulating the black market. Generic tabs are also available and these two forms represent a very cost-effective alternative for buying the brand name drug.

Exeplex

Average Dose: .
Half Life: 5 - 7 days
Water Retention: none
Aromatization: no
DHT Conversion: no

Exemestane (Exeplex) is an oral steroidal aromatase inhibitor (but also known uniquely as an aromatase inactivator) used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. The aim of Exeplex is to lower estrogen levels.

Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." In other words, the Exemestane, by being structurally similar to the target of the enzymes, permanently binds to those enzymes, thereby preventing them from ever completing their task of converting androgens into estrogen.

The estrogen suppression rate for exemestane varies from 85% to 95%.

Duraplex 100

Average Dose: 400 - 500mg/week (M) 100mg/week (F)
Half Life: 72 hours
Water Retention: Yes, some
Aromatization: Low
DHT Conversion: None

Duraplex 100 for intramuscular injection, contains nandrolone phenylpropionate

Nandrolone phenylpropionate is a fast-acting form of nandrolone. Nandrolone is chemically related to the male hormone testosterone. Compared to testosterone, it has an enhanced anabolic and a reduced androgenic activity. This has been demonstrated in animal bioassays and explained by receptor binding studies. The low androgenicity of nandrolone is confirmed in clinical use. In the human, nandrolone has been shown to positively influence calcium metabolism and to increase bone mass in osteoporosis. In women with disseminated mammary carcinoma, nandrolone has been reported to produce objective regressions for many months. Furthermore, nandrolone has a nitrogen-saving action. This effect on protein metabolism has been established by metabolic studies and is utilised therapeutically in conditions where a protein deficiency exists such as during chronic debilitating diseases and after major surgery and severe trauma. In these conditions, nandrolone phenylpropionate serves as a supportive adjunct to specific therapies and dietary measures as well as parenteral nutrition, due to it's faster acting nature nandrolone phenylpropionate is preffered in situations where a faster clinical response is required over it's chemical variant nandrolone decaonate(Decaplex).

Clomiplex

Average Dose: 50-100 mg/day
Half Life: 5 - 7 days
Water Retention: No
Aromatization: none

Clomiplex (CLomid) is a brand name for the drug clomiphene citrate. Clomid is typically prescribed for women to aid in ovulation. In men, the application of Clomid causes an elevation of follicle stimulating hormone and luteinizing hormone. As a result, natural testosterone production is also increased. This effect is obviously beneficial to the athlete, especially at the conclusion of a cycle when endogenous testosterone levels are subnormal. When an athlete discontinues the use of steroids, his testosterone levels will most likely be suppressed. If endogenous testosterone levels are not brought to normal, a dramatic loss in size and strength may occur. Clomid plays a crucial role in preventing this crash in athletic performance. Bodybuilders find that a daily intake of 50-100 mg of clomiphene citrate over a two week period will bring endogenous testosterone production back to an acceptable level. Clomid will gradually raise testosterone levels over its period of intake. Since an immediate boost in testosterone is often desirable, athlete will commonly use HCG (human chorionic gonadotropin) for a couple of weeks, and then continue treatment with Clomid. Clomid is also effective as an anti-estrogen. Most athletes will suffer from an elevated estrogen level at the conclusion of a cycle. A high estrogen level combined with a low testosterone level puts an athlete in serious risk of developing gynocomastia. With the intake of Clomid, the athlete gets the dual effect of blocking out some of the effects of estrogen, while also increasing endogenous testosterone production. In relation to toxicity and side effects, Clomid is considered a fairly safe drug. Bodybuilders seldom experience any problems, but possible side effects include hot flashes and temporary blurred vision. Clomiphene citrate is widely available on the black market. Until recently, it was relatively easy to get through foreign mail order. However, since the DEA is playing an active role in pursuing mail-order operations catering to athletes, Clomid is becoming harder to obtain.

Avodart

Adovart, aka dutasteride 0.5mg, is a prostate medication much like Proscar and Propecia, which contain finasteride. One effect of both medications, dutasteride and finasteride, is that they prevent the conversion of testosterone into DHT, which is known to be a factor in hair loss.

Arimiplex

Average Dose: .25mg - 1mg per day
Half Life: 5 - 7 days
Water Retention: none
Aromatization: no
DHT Conversion: no

Arimidex is not a steroid. It is a tablet form anti-aromitase that is used by many body builders to help prevent bloating (edema) and Gynecomastia (bitch tit) associated with the use of testosterone and androgens. It can be used in place of Nolvadex,Clomid, etc. Bodybuilders are using around .25mg to 1mg per day or .5mg to 1mg every other day and are having good success with it.

The FDA approved uses are for the treatment of breast cancer in post-menopausal women with disease progression following tamoxifen therapy. Hypersensitivity to anastrozole are reasons not to use this drug. If you have these problems please inform your doctor. Common side effects are: shortness of breath, dizziness, diarrhea, vomiting, headache, hat flashes, weakness, cough, dry mouth, skin rash, sweating, abdominal pain and bone pain. Some less common symptoms are vaginal bleeding, weight gain, tiredness, chills, fever, breast pain, and itching. In case of an overdose, it is recommended to contact your poison control center.

DNP

Average Dose: 200 - 400mg per day for the first 4 days

DNP (2,4-Dinitrophenol), an industrial chemical with various applications, has gained steady popularity as a fat loss tool. Boasting an astounding 50% increase in metabolic rate, it is able to contribute to reported fat losses of 10-12 pounds in 8 days of use. Classified as an "uncoupler of oxidative phosphorylation" medically, it is quite dangerous as there is no negative feedback system that may deal with overdoses. Specifically, there is no upper limit to the increase in body temperature that may be obtained with its use.

Introduction/History

Competitive bodybuilders and many others are continually on a quest for leanness. Used by the hardcore since Dan Duchaine's reporting of it a couple years ago, DNP (2,4-Dinitrophenol) has managed to steadily gain popularity as a powerful tool for weight loss. Interestingly, DNP was first used to ignite TNT in the early 1900s. In 1931 a study released by Stanford University declared that DNP was able to cause amazing weight loss; subsequently it found its way into many diet potions and medications; regulation was much less strict during this time than the present, and many of these products were available over the counter. Two years later DNP was banned by the FDA as a dieting agent due to its inclusion in many OTC dietary supplements. The FDA was a new organization at this time and acted in a rather brazen manner, with the absence of any set procedures for taking substances off the market. Granted, there was only a 1% incidence of cataracts over a large population (around 100,000); nonetheless it happened (although interestingly, exclusively women). However, there are now ways to counter this which will be covered thoroughly.

The comparisons to the current drugs used for dieting are astounding, at least in terms of thermogenesis. While the ECA stack has been shown to provide approximately a 3% increase in metabolic rate, DNP can deliver a relatively controlled 50% elevation in resting metabolic rate. The thermogenic aspect of clenbuterol, while sometimes overestimated due to the high CNS stimulation that yields a "wired" feeling, can vary according to prior exposure to various amphetamine-like compounds and certainly is not much greater than that of ECA. DNP does not have the anorectic effects of ephedrine or other thermogenic agents; rather, it tends to increase hunger, particularly appetite for carbohydrates. This problem is easily solved with appetite suppressants, and one may even use ECA itself for this purpose while on DNP.

Molecular Basis for Efficacy

DNP accomplishes the astounding boost in metabolic rate via inhibition of the F0F1 ATP synthase molecule, located in the inner wall of each mitochondrion. While the electron transport chain still functions to pump hydrogen ions into the intermembrane space, the coupling of the proton gradient to ATP production is rendered impossible by DNP. As a result, ATP production is dramatically reduced, and the energy is instead thrown off as heat. This results in an astounding production of heat; when using dinitrophenol, the athlete will radiate so much heat that it is uncomfortable to be within any proximity of them. Luckily, this heat does not fully contribute to body temperature increases, and is instead thrown off from the entire body surface, particularly the head. As a result, adequate doses of DNP will usually only elevate body temperature by about 1-1.5ºC. This is a good thing for your central nervous system and other delicate tissues; if the heat produced by ATP contributed in a more direct matter to body temperature, effective doses for fat loss would cause supraphysiological body temperature increases on a level unwitnessed at this time. Nonetheless, overheating is a very real danger; this and other side effects shall now be addressed.

Risks/Side Effects

Hearing all of these wonderful things probably has you wondering what the side effects and risks are. They are quite formidable and contribute to making DNP one of the most intolerable (though effective) drugs used in bodybuilding. Starting with the most significant, and descending in importance, are the following risks and side effects of DNP use.

Trinaplex 200

Average Dose: 150 - 300mg per week
Half Life: multi ester
Water Retention: no
Aromatization: no
DHT Conversion: no

Trinaplex E 200 for intramuscular injection contains trenbolone acetate, trenbolone hexahydrobenzylcarbonate and trenbolone enanthate. The presence of the acetate ester allows Trinaplex E 200 to display a rapid initial physiological response. The hexahydrobenzylcarbonate and enanthate esters, which release at slower rates, prolong the physiological response with a relatively flat absorption curve over the duation of the injection life-cycle.

Bodybuilders have been known to use the drug in order to increase body mass more effectively than by weight training alone. A normal bodybuilding dosage can range from 200 mg/week up to 1400 mg/week.

The 2006 book Game of Shadows alleges that baseball superstar Barry Bonds used this drug in 2001, when he set the current single-season home run record.

Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of testosterone. Once metabolised, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Trenbolone has proven popular with anabolic steroid users as it is not metabolised by aromatase or 5α-reductase into estrogenic compounds such as estradiol, or into DHT. This means that it also does not cause any water retention normally associated with highly androgenic steroidal compounds like testosterone or methandrostenolone. It is also loved by many for the dramatic strength increases commonly experienced with it. Some short-term side effects include insomnia, high blood pressure, increased aggression and libido. However, since women will suffer virilization effects even at small doses, this drug should not be taken by a female. Urban wisdom/myth in bodybuilding culture, states that the use of the drug over extended periods of time can lead to kidney damage. The kidney toxicity has not yet been proven, and scientific evidence supporting the idea is suspiciously absent from the bodybuilding community that perpetuates this idea. The origin of this myth most likely has to do with the rust colored oxidized metabolites of trenbolone which are excreted in urine and often mistaken for blood. After Schänzer (Clin Chem 1996; 42(7): 1001-1020, Metabolism of anabolic androgenic steroids) trenbolone and 17epi-trenbolone are both excreted (in urine) as conjugates that can be hydrolyzed with beta-glucuronidase. This implies that trenbolone leaves the body as beta-glucuronides or sulfates, that means mostly non metabolized.

Turanaplex

Average Dose: 20mg per day
Half Life: 8 hours
Water Retention: minimal to zero
Aromatization: No
DHT Conversion: none

OT has a predominantly anabolic effect which is combined with a relatively low androgenic component. On a scale of 1 to 100 the androgenic effect is very low only a 6- and the anabolic effect is 53. (In comparison: the androgenic effect of Dianabol is 45 and its anabolic effect is 90.) Oral-Turanaplex thus has milligram for milligram a lower effect than Dianabol. It is therefore not a steroid that causes a rapid gain in strength, weight, and muscle mass. Rather, the achievable results manifest themselves in a solid muscle gain and, if taken over several weeks, also in a good strength gain. The athlete will certainly not get a puffy look as is the case with Testosterone, Dianabol, and Anadrol 50. The maximum blood concentration of Oral-Turinabol when taking 10, 20 or 40 mg/day is 1.5 -3.5 or 4.5 times the endogenous testosterone concentration (also see Dianabol). This clearly shows that the effectiveness of this compound strongly depends on the dosage.

0.4 x pound (body weight) x days = number of tablets to take overall during the interval of intake mg / tablet

An athlete weighing 200 pounds would take only 2 tablets of 10 mg (20mg/day.) Bodybuilders take 8-10 tablets of 5 mg, that is 40-50 mg/day. Many enthusiastically report good results with this dosage: one builds a solid muscle mass, the strength gain is worthwhile seeing, the water retention is very low, and the estrogen caused side effects are rare. Not without good reason OT is also popular among powerlifters and weightlifters who appreciate these characteristics.

Due to its characteristics OT is also a suitable steroid both for men and women in competitions. A usually very effective stack for male bodybuilders consists of 50 mg OT/day, 228 mg Parabolan/week, and 150 mg Winstrol Depot/week. Those who have brought their body fat content to a low level by dieting and/or by using fatburning substances (e.g. Clenbutaplex, Ephedrine, Salbutamol, Cytomel, Triacana), will find that the above steroid combination will manifest itself in hard, sharply defined but still dense and full muscles. No enlarged breasts, no estrogen surplus, and no watery, puffy looking muscle system. If OT were available on the U.S. black market for steroids, bodybuilders, powerlifters, and weightlifters would go crazy for this East German anabolic.

OT enjoys a great popularity since it is quickly broken down by the body and the metabolites are excreted relatively quickly through the urine. The often posed question regarding how many days before a test OT can be taken in order to be "clean" is difficult to answer specifically or in general. We know from a reli-able source that athletes who only take OT as a steroid and who, in part, take dosages of 10- 15 tablets/day, have discontinued the com-pound exactly five days before a doping test and tested negative. These indications are supported by the fact that even positive urine analyses have rarely mentioned the names Oral-Turanaplex or chlordehydromethyl-testosterone.

The potential side effects of OT usually depend on the dosage level and are gender-specific. in women, depending on their predisposition, the usual virilization symptoms occur and increase when dosages of more than 20 mg per day are taken over a prolonged time. In men the already discussed reduced testosterone production can rarely be avoided. Gynecomastia occurs rarely with OT Since the response of the water and electrolyte household is not overly dis-tinct athletes only rarely report water retention and high blood pressure. Acne, gastrointestinal pain, and uncontrolled aggressive behavior are also the exception rather than the rule with OT An increased libido is reported in most cases by both sexes. Since the substance chlordehydromethyltestosterone is 17-alpha alkylated the manufacturer in its package insert recommends that the liver func-tion be checked regularly since it can be negatively affected by high dosages and the risk of possible liver damage cannot be excluded. Thus OT is also a steroid that can be taken without interruption for long intervals. Studies of male athletes who over a period of six weeks were given 10 mg OT/day did not show any indications of health-threatening effects.

Trenaplex D 100

Average Dose: 200 - 300mg per week
Half Life: 4 days
Water Retention: no
Aromatization: no
DHT Conversion: no

Trenaplex D 100 for intramuscular injection, contains trenbolone hexahydrobenzylcarbonate

To increase its effective half-life, trenbolone is not used in an unrefined form, but is rather administered as trenbolone acetate ,enanthate or Hexahydrobenzylcarbonate. Trenbolone is then produced as a metabolite by the reaction of these compounds with the androgen receptor.

Bodybuilders have been known to use the drug in order to increase body mass more effectively than by weight training alone. A normal bodybuilding dosage can range from 200 mg/week up to 1400 mg/week. Due to the relatively short metabolic half-life of trenbolone acetate, dosages should commonly be split into injections at least once every two days. Trenbolone enanthate can be injected once a week.Trenbolone hexahydrobenzylcarbonate can be injected even less frequently than trenbolone enanthate.

The 2006 book Game of Shadows alleges that baseball superstar Barry Bonds used this drug in 2001, when he set the current single-season home run record.

Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of testosterone.[citation needed] Once metabolised, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Trenbolone has proven popular with anabolic steroid users as it is not metabolised by aromatase or 5α-reductase into estrogenic compounds such as estradiol, or into DHT. This means that it also does not cause any water retention normally associated with highly androgenic steroidal compounds like testosterone or methandrostenolone. It is also loved by many for the dramatic strength increases commonly experienced with it. Some short-term side effects include insomnia, high blood pressure, increased aggression and libido. However, since women will suffer virilization effects even at small doses, this drug should not be taken by a female. Urban wisdom/myth in bodybuilding culture, states that the use of the drug over extended periods of time can lead to kidney damage. The kidney toxicity has not yet been proven, and scientific evidence supporting the idea is suspiciously absent from the bodybuilding community that perpetuates this idea. The origin of this myth most likely has to do with the rust colored oxidized metabolites of trenbolone which are excreted in urine and often mistaken for blood. After Schänzer (Clin Chem 1996; 42(7): 1001-1020, Metabolism of anabolic androgenic steroids) trenbolone and 17epi-trenbolone are both excreted (in urine) as conjugates that can be hydrolyzed with beta-glucuronidase. This implies that trenbolone leaves the body as beta-glucuronides or sulfates, that means mostly non metabolized.

Mastaplex 100

Average Dose: 300 - 500mg per week
Half Life: 2 - 3 days
Water Retention: No
Aromatization: No
DHT Conversion: No

Mastaplex is a synthetic derivative of dihydrotestosterone, displaying a potent androgenic effect that is responsible for increases in muscle density and hardness and a moderate anabolic effect that creates a positive nitrogen balance in humans and promotes protein synthesis. Since it is a derivative of dihydrotestosterone, dromastanolone does not aromatize at any dosage and thus it cannot be converted into estrogen. Therefore, estrogen-related water retention is eliminated. Mastabol 100 is relatively fast-actiing and fast-clearing because of the attachment of the propionate ester to the base molecule.

Trenaplex A 100

Average Dose: 50 - 200mg per day
Half Life: 48 - 72 hours hours
Water Retention: No
Aromatization: No
DHT Conversion: No

Trenaplex A 100 for intramuscular injection, contains Trenbolone Acetate. Trenbolone Acetate is a fast acting injectable steroid.

To increase its effective half-life, trenbolone is not used in an unrefined form, but is rather administered as trenbolone acetate ,enanthate or Hexahydrobenzylcarbonate. Trenbolone is then produced as a metabolite by the reaction of these compounds with the androgen receptor.

Bodybuilders have been known to use the drug in order to increase body mass more effectively than by weight training alone. A normal bodybuilding dosage can range from 200 mg/week up to 1400 mg/week. Due to the relatively short metabolic half-life of trenbolone acetate, dosages should commonly be split into injections at least once every two days. Trenbolone enanthate can be injected once a week.

The 2006 book Game of Shadows alleges that baseball superstar Barry Bonds used this drug in 2001, when he set the current single-season home run record.

Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of testosterone. Once metabolised, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Trenbolone has proven popular with anabolic steroid users as it is not metabolised by aromatase or 5α-reductase into estrogenic compounds such as estradiol, or into DHT. This means that it also does not cause any water retention normally associated with highly androgenic steroidal compounds like testosterone or methandrostenolone. It is also loved by many for the dramatic strength increases commonly experienced with it. Some short-term side effects include insomnia, high blood pressure, increased aggression and libido. However, since women will suffer virilization effects even at small doses, this drug should not be taken by a female. Urban wisdom/myth in bodybuilding culture, states that the use of the drug over extended periods of time can lead to kidney damage. The kidney toxicity has not yet been proven, and scientific evidence supporting the idea is suspiciously absent from the bodybuilding community that perpetuates this idea. The origin of this myth most likely has to do with the rust colored oxidized metabolites of trenbolone which are excreted in urine and often mistaken for blood. After Schänzer (Clin Chem 1996; 42(7): 1001-1020, Metabolism of anabolic androgenic steroids) trenbolone and 17epi-trenbolone are both excreted (in urine) as conjugates that can be hydrolyzed with beta-glucuronidase. This implies that trenbolone leaves the body as beta-glucuronides or sulfates, that means mostly non metabolized.

Testaplex P 100

Average Dose: 50-200 mg/day
Half Life: 48 - 72 hours
Water Retention: slight
Aromatization: Yes
DHT Conversion: Yes

Testosterone propionate is a male sexual hormone with pronounced, mainly androgenic action, possessing the biological and therapeutic properties of the natural hormone. In a healthy male organism, androgens are formed by the testes and adrenal cortex. It is normally produced in women in small physiological quantities. In addition to the specific action that determines the sexual characteristics of the individual, it also has a general anabolic action, manifested in enhancement of protein synthesis. Under the effect of testosterone, body weight increases and urea excretion is reduced. High doses suppress the production of hypophyseal gonadotropin, while low doses stimulate it. It has an antitumor effect on mammary gland metastases.

Testaplex C 200

Average Dose: 250-1000 mg/week
Half Life: 14 - 16 days
Water Retention: High
Aromatization: High
DHT Conversion: High

Tetsaplex C 200 injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)-cyclopentylpropionate ester of the androgenic hormone testosterone.

Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor.

Primoplex 100

Average Dose: 200-400mg/week(M) 50-100mg/week(F)
Half Life: 10 - 14 days
Water Retention: Low
Aromatization: none
DHT Conversion: none

Primoplex 100 (Methenolone Enanthate) is a DHT based anabolic steroid. Known under the brand name of Primoplex® in tablet or injectable form.

When it interacts with the aromatase enzyme it does not form any estrogens. It is used by people who are very succeptible to estrogenic side effects, having lower estrogenic properties than Nandrolone. Methenolone is available as an injection or as an oral(primoplex). The injection is naturally regarded as having a higher bioavailability. Its an enanthate ester which is quite long-acting. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The tablets are in a short-lived acetate form. Methenolone is not 17-alpha-alkylated, but 1-methylated for oral bioavailability. This reduces the stress on the liver, but also the availability. It is considered one of the safer steroids, meaning it has a very little side effects. Methenolone has no estrogenic side effects, and its effects on cholesterol levels are minimal. In doses of 200 mg or less (intramuscular) blood pressure is rarely altered.

Possibly one of the safer anabolic steroids for females due to very low virilization effects in short-term usage. Of course, this is not a blanket-statement and individual results (dependent on doses and tolereance) will vary.

Methenolone is also not overly suppressive of the HPTA axis, although how suppressive is debatable. For this reason, many bodybuilders use it in between steroid cycles during their "off-time" to help maintain their gains and strength. The long term safety of such a practice possibly dangerous and can lead to permanent suppression of the HPTA.

Arnold Schwarzenegger is rumored to have introduced methenolone to the US bodybuilding community.

Equiplex 200

Average Dose: 400-600mg/week(M) 50-150 mg/week(F)
Half Life: 14 - 16 days
Water Retention: Low
Aromatization: Mild
DHT Conversion: Low

Equiplex more known as trade name Equipoise. It is a favorite veterinary steroid of many athletes. Its effects are strongly anabolic, and only moderately androgenic. By itself, Equiplex will provide a steady and consistent gain in mass and strength. However, best results are achieved when Equipoise is used in conjunction with other steroids. Equipoise is a favorite veterinary steroid of many athletes. Its effects are strongly anabolic, and only moderately androgenic. By itself, Equiplex will provide a steady and consistent gain in mass and strength. However, best results are achieved when Equiplex is used in conjunction with other steroids.For mass, Equiplex stacks exceptionally well with Methanoplex, Oxyplex or an injectable testosterone like Sustaplex 325or Testaplex C. Equiplex is also highly effective for contest preparation since it aromatizes very poorly. Muscle hardness and density can be greatly improved when Equiplex is combined with Enanthate or Winstrol. Average dosages of Equiplex are 200-600 mg per week.Injections are usually taken every other day. If high volume injections are made too frequently to the same injection site, an oil abscess may form. An oil abscess will often dissipate on its own, but in extreme instances, a doctor will need to drain it. Therefore, athletes should take caution and rotate injection sites. It is packed in multiple dose vial of 10 ml 200 mg per ml.

Decaplex 275

Average Dose: 300-800 mg/week(M) 50-100 mg/week(F)
Half Life: Two Weeks
Water Retention: Yes, some
Aromatization: Low
DHT Conversion: No

World wide "Deca" is one of the most widely used anabolic steroids. Its popularity is due to the simple fact that it exhibits many very favorable properties. Structurally nandrolone is very similar to testosterone, although it lacks a carbon atom at the 19th position (hence its other name 19-nortestosterone). The resulting structure is a steroid that exhibits much weaker androgenic properties than testosterone. Of primary interest is the fact that nandrolone will not break down to a more potent metabolite in androgen target tissues. You may remember this is a significant problem with testosterone. Although nandrolone does undergo reduction via the same (5-alpha reductase) enzyme that produces DHT from testosterone, the result in this case is dihydronandrolone. This metabolite is weaker than the parent nandroloness, and is far less likely to cause unwanted androgenic side effects. Strong occurrences of oily skin, acne, body/facial hair growth and hair loss occur very rarely. It is however possible for androgenic activity to become apparent with this as any steroid, but with nandrolone higher than normal doses are usually responsible.

Nandrolone also show an extremely lower tendency for estrogen conversion. For comparison, the rate has been estimated to be only about 20% of that seen with testosterones. This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process". Consequently estrogen related side effects are a much lower concern with this drug. An anti-estrogen is likewise rarely needed with Deca, gynecomastia only a worry among sensitive individuals. At the same time water retention is not a usual concern. This effect can occur however, but is most often related to higher dosages. The addition of Proviron and/or Nolvadex should prove sufficient enough to significantly reduce any occurrence. Clearly Deca is a very safe choice among steroids. Actually, many consider it to be the best overall steroid for a man to use when weighing the side effects and results. It should also be noted that in HIV studies, Deca has been shown not only to be effective at safely bringing up the lean body weight of patient, but also to be beneficial to the immune system.

It is of note however that nandrolone is believed to have some activity as a progestin in the body. Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well. This can lead to some progestin-like activity in the body, and may intensify related side effects. The side effects associated with progesterone are actually quite similar to those of estrogen, including negative feedback inhibition of testosterone production, enhanced rate of fat storage and possibly gynecomastia. Many believe the progestin activity of DecabolÂ® notably contributes to suppression of testosterone synthesis, which can be marked despite a low tendency for estrogen conversion.

Decabol is not known as a very "fast" builder. The muscle building effect of this drug is quite noticeable, but not dramatic. The slow onset and mild properties of this steroid therefore make it more suited for cycles with a longer duration. In general one can expect to gain muscle weight at about half the rate of that with an equal amount of testosterone. A cycle lasting eight to twelve weeks seems to make the most sense, expecting to elicit a slow, even gain of quality mass. Although active in the body for much longer, DecabolÂ® is usually injected once or twice per week. The dosage for men is usually in the range of 300-600mg/week. If looking to be specific, it is believed that Decabol will exhibit its optimal effect (best gain/side effect ratio) at around 2mg per pound of lean bodyweight/weekly. DecabolÂ® is also a popular steroid among female bodybuilders. They take a much lower dosage on average than men of course, usually around 50mg weekly. Although only slightly androgenic, women are occasionally confronted with virilization symptoms when taking this compound. Should this become a concern, the shorter acting nandrolone Durabolin would be a safer option. This drug stays active for only a few days, greatly reducing the impact of androgenic buildup if withdrawal were indicated.

Endogenous testosterone levels can be a concern with DecabolÂ®, especially after long cycles. It is therefore mandatory to incorporate ancillary drugs at the conclusion of therapy. An estrogen antagonist such as Clomid or Nolvadex is therefore commonly used for a few weeks. These both provide a good level of testosterone stimulation, although they may take a couple of weeks to show the best effect. HCG injections could be added for extra reassurance, acting to rapidly restore the normal ability of the testes to respond to the resumed release of gonadotropins. For this purpose one could administer three injections of 2500-50001.U., spaced five days apart. After which point the antagonist is continued alone for a few more weeks in an effort to stabilize the production of testosterone. Remember not to begin post cycle therapy (PCT) until after Deca has been withdrawn for around three weeks. Deca stays active for quite some time so the ancillary drugs will not be able to exhibit their optimal effect when the steroid is still being released into the bloodstream. The major drawback for competitive purposes is that in many cases nandrolone metabolites will be detectable in a drug screen for up to a year (or more) after use. This is clearly due to the form of administration. Esterified compounds have a high affinity to stay stored in fatty tissues. While we can accurately estimate the time frame it will take for a given dose to enter circulation from an injection site, we cannot know for sure that 100% of the steroid will have been metabolized at any given point. Small amounts may indeed be stubborn in leaving fatty tissue, particularly after heavy, longer-term use. Some quantity of nandrolone decanoate may therefore be left to sporadically enter into the blood stream many months after use. This process may be further aggravated when dieting for a show, a time when body fat stores are being actively depleted (possibly freeing more steroid). This has no doubt been the cause for many unexpected positives on a drug screen. The fact that nandrolone has been isolated as the "hands-off" injectable for the drug tested athlete is most likely due to its popularity (and therefore common appearance on drug screens). The same risk would of course hold true for other long chain esterified injectables such as Boldabol (Equipoise), and Primobol (Primobolan).

Those not worried about drug screens are likely to find the low water retention and good effect of this drug favorable for use in pre-contest cutting stacks. A combination of Decabol and Stanabol during the weeks/months leading up to a show for example, is noted to greatly enhance to look of muscularity and definition. A strong non-aromatizing androgen like Halotestin or trenbolone could be further added, providing an enhanced level of hardness and density to the muscles. Being an acceptable anabolic, Deca can also be incorporated into bulk cycles with good results. The classic Deca and Dianabol cycle has been a basic for decades, and always seems to provide excellent muscle growth. A stronger androgen such as Anadrol or testosterone could also be substituted, producing greater results. When mixed with Deca, the androgen dosage can be kept lower than if used alone, hopefully making the cycle more comfortable. Additionally one may choose to continue Deca for a number of few weeks after the androgen has been stopped. This will hopefully harden up some of the bloat produced by the androgen, giving a more quality appearance. Remember that endogenous testosterone production will not resume during Deca therapy, and ancillaries are likewise still needed.

Trenaplex E 200

Average Dose: 200 - 400mg per week
Half Life: 12 - 14 days
Water Retention: no
Aromatization: no
DHT Conversion: no

Trenaplex E 200 for intramuscular injection, contains Trenbolone Enanthate. Trenbolone Enanthate is a long acting injectable steroid.

To increase its effective half-life, trenbolone is not used in an unrefined form, but is rather administered as trenbolone acetate ,enanthate or Hexahydrobenzylcarbonate. Trenbolone is then produced as a metabolite by the reaction of these compounds with the androgen receptor.

Bodybuilders have been known to use the drug in order to increase body mass more effectively than by weight training alone. A normal bodybuilding dosage can range from 200 mg/week up to 1400 mg/week. Due to the relatively long metabolic half-life of trenbolone enanthate dosages should be once a week. Trenbolone acetate injections are commonly split into at least once every two days.

The 2006 book Game of Shadows alleges that baseball superstar Barry Bonds used this drug in 2001, when he set the current single-season home run record.

Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of testosterone. Once metabolised, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Trenbolone has proven popular with anabolic steroid users as it is not metabolised by aromatase or 5α-reductase into estrogenic compounds such as estradiol, or into DHT. This means that it also does not cause any water retention normally associated with highly androgenic steroidal compounds like testosterone or methandrostenolone. It is also loved by many for the dramatic strength increases commonly experienced with it. Some short-term side effects include insomnia, high blood pressure, increased aggression and libido. However, since women will suffer virilization effects even at small doses, this drug should not be taken by a female. Urban wisdom/myth in bodybuilding culture, states that the use of the drug over extended periods of time can lead to kidney damage. The kidney toxicity has not yet been proven, and scientific evidence supporting the idea is suspiciously absent from the bodybuilding community that perpetuates this idea. The origin of this myth most likely has to do with the rust colored oxidized metabolites of trenbolone which are excreted in urine and often mistaken for blood. After Schänzer (Clin Chem 1996; 42(7): 1001-1020, Metabolism of anabolic androgenic steroids) trenbolone and 17epi-trenbolone are both excreted (in urine) as conjugates that can be hydrolyzed with beta-glucuronidase. This implies that trenbolone leaves the body as beta-glucuronides or sulfates, that means mostly non metabolized.

Tamoxiplex

TAMOXIPLEX is effective in the treatment of metastatic breast cancer in women and men. In premenopausal women with metastatic breast cancer, TAMOXIPLEX is an alternative to oophorectomy or ovarian irradiation . Available evidence indicates that patients whose tumors are estrogen receptor positive are more likely to benefit from TAMOXIPLEX therapy .

Adjuvant Treatment of Breast Cancer

TAMOXIPLEX is indicated for the treatment of node-positive breast cancer in women following total mastectomy or segmental mastectomy, axillary dissection , and breast irradiation. In some TAMOXIPLEX adjuvant studies, most of the benefit to date has been in the subgroup with four or more positive axillary nodes.

TAMOXIPLEX is indicated for the treatment of axillary node-negative breast cancer in women following total mastectomy or segmental mastectomy, axillary dissection , and breast irradiation.

The estrogen and progesterone receptor values may help to predict whether adjuvant TAMOXIPLEX therapy is likely to be beneficial.

TAMOXIPLEX reduces the occurrence of contralateral breast cancer in patients receiving adjuvant TAMOXIPLEX therapy for breast cancer.

Ductal Carcinoma in Situ ( DCIS )

In women with DCIS, following breast surgery and radiation , TAMOXIPLEX is indicated to reduce the risk of invasive breast cancer (see BOXED WARNING at the beginning of the label). The decision regarding therapy with TAMOXIPLEX for the reduction in breast cancer incidence should be based upon an individual assessment of the benefits and risks of TAMOXIPLEX therapy.

Current data from clinical trials support five years of adjuvant TAMOXIPLEX therapy for patients with breast cancer.

Reduction in Breast Cancer Incidence in High Risk Women

TAMOXIPLEX is indicated to reduce the incidence of breast cancer in women at high risk for breast cancer. This effect was shown in a study of 5 years planned duration with a median follow-up of 4.2 years. Twenty-five percent of the participants received drug for 5 years. The longer-term effects are not known. In this study, there was no impact of tamoxifen on overall or breast cancer-related mortality

Testaplex E 250

Average Dose: 250-1000 mg/week
Half Life: 14 - 16 days
Water Retention: high
Aromatization: high
DHT Conversion: high

Tetsaplex E 250 injection, for intramuscular injection, contains testosterone enanthate which is insoluble in water, very soluble in ether and soluble in vegetable oils.

Androgens are derivatives of cyclopentano-perhydrophenanthrene. Endogenous androgens are C-19 steroids with a side chain at C-17, and with two angular methyl groups. Testosterone is the primary endogenous androgen.

In their active form, all drugs in the class have a 17-beta-hydroxy group. Esterification of the 17-beta-hydroxy group produces compounds (testosterone enanthate and testosterone propionate) which have a longer duration of action and are hydrolyzed in vivo to free testosterone.

Androgens are steroids that develop and maintain primary and secondary male sex characteristics.

Endogenous androgens are responsible for the normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include the growth and maturation of prostate, seminal vesicles, penis, and scrotum; the development of male hair distribution, such as beard, pubic, chest and axillary hair; laryngeal enlargement, vocal chord thickening, alterations in body musculature, and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for the eventual termination of linear growth which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth center and termination of growth process.

Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietic stimulating factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

Sustaplex 325

A perfect blend of five testosterone compounds. The five different testosterone esters provide for different half lives. Esterization of the testosterone molecules provides for a sustained (but non-linear) release of testosterone from the injection depot into the blood plasma.

While the intention of the mixed testosterone esters in Sustaplex is to provide more stable serum testosterone levels, the long-ester testosterones, such as testosterone cypionate or testosterone decanoate, provide more stable serum testosterone levels.

Sustaplex is the most popular testosterone blend product among those that use anabolic steroids for muscle building purposes.

Stanoplex 10

Methanoplex 10

Oxandroplex - Anavar

Average Dose: 20-50 mg/day(M) Women 5-15 mg/day(F)
Half Life: 8 - 12 hours
Water Retention: Rare
Aromatization: None
DHT Conversion: Low

This product is 4 times more potent than conventional Anavar (Oxandrolone) It works well for the promotion of strength and duality muscle mass gains, although it"s mild nature makes it less than ideal for bulking purposes. Among bodybuilders it is most commonly used during cutting phases of training when water retention is a concern. The standard dosage for men is in the range of 20-50mg per day, a level that should produce noticeable results. It can be further combined with anabolics like Primoplex and Stanoplex to elicit a harder, more defined look without added water retention. Such combinations are very popular and can dramatically enhance the show physique. One can also add strong non-aromatizing androgens like Haloplex, Proviraplex or Trenaplex. In this case the androgen really helps to harden up the muscles, while at the same time making conditions more favorable for fat reduction. Some athletes do choose to incorporate Oxandroplex into bulking stacks, but usually with standard bulking drugs like testosterone or Methanoplex. The usual goal in this instance is an additional gain of strength, as well as more quality look to the androgen bulk. Women who fear the masculinizing effects of many steroids would be quite comfortable using this drug, as this is very rarely seen with low doses. Here a daily dosage of 5mg should illicit considerable growth without the noticeable androgenic side effects of other drugs. Eager females may wish to addition mild anabolics like Stanoplex, Primoplex or Duraplex. When combined with such anabolics, the user should notice faster, more pronounced muscle-building effects, but may also increase the likelihood of androgenic buildup.

Studies using low dosages of this compound note minimal interferences with natural testosterone production. Likewise when it is used alone in small amounts there is typically no need for ancillary drugs like Clomid/Arimiplex or HCG. This has a lot to do with the fact that it does not convert to estrogen, which we know has an extremely profound effect on endogenous hormone production. Without estrogen to trigger negative feedback, we seem to note a higher threshold before inhibition is noted. But at higher dosages of course, a suppression of natural testosterone levels will still occur with this drug as with any anabolic/androgenic steroid and therefore require post cycle therapy to restore the HPTA.

Oxandroplex is also a 17alpha alkylated oral steroid, carrying an alteration that will put stress on the liver. It is important to point out however that dispite this alteration oxandrolone is generally very well tolerated. While liver enzyme tests will occasionally show elevated values, actual damage due to this steroid is not usually a problem. Bio-Technology General states that Oxandroplex is not as extensively metabolized by the liver as other l7aa orals are; evidenced by the fact that nearly a third of the compound is still intact when excreted in the urine. This may have to do with the understood milder nature of this agent (compared to other l7aa orals) in terms of hepatotoxicity. One study comparing the effects of Oxandroplex to other agents including as methyltestosterone, norethandrolone, fluoxymesterone and methAndriol clearly supports this notion. Here it was demonstrated that Oxandroplex causes the lowest sulfobromophthalein (BSP; a marker of liver stress) retention among all the alkylated orals tested. 20mg of oxandrolone in fact produced 72% less BSP retention than an equal dosage of fluoxyrnesterone, which is a considerable difference being that they possess the same liver-toxic alteration. With such findings, combined with the fact that athletes rarely report trouble with this drug, most feel comfortable believing it to be much safer to use during longer cycles than most of other orals with this distinction. Although this may very well be true, the chance of liver damage still cannot be excluded, especially with hogher dosages.

At one time oxandrolone was also looked at as a possible drug for those suffering from disorders of high cholesterol or triglycerides. Early studies showed it to be capable of lowering total cholesterol and triglyceride values in certain types of hyperlipidemic patients, which initially this was thought to signify potential for this drug as a hypo-lipid (lipid lowering) agent. With further investigation we find however that while use of this drug can be linked to a lowering of total cholesterol values, it is such that a redistribution in the ratio of good (HDL) to bad (LDL) cholesterol occurs, usually moving values in an unfavorable direction. This would of course negate any positive effect that the drug might have on triglycerides or total cholesterol, and in fact make it a danger in terms of cardiac risk when taken for prolonged periods of time. Today we understand that as a group anabolic/androgenic steroids produce very unfavorable changes in lipid profiles, and are really not useful in disorders of lipid metabolism. As an oral c17 alpha alkylated steroid, oxandrolone is probably even more risky to use than an injectable esterified injectable such as a testosterone or nandrolone in this regard.